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    DE DIETRICH is the world's leading provider of engineered systems, process equipment and solutions for the pharmaceutical, food, green chemistry and chemical industries.

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DE DIETRICH is the world's leading provider of engineered systems, process equipment and solutions for the pharmaceutical, food, green chemistry and chemical industries.

  1. Home
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Process Systems

- Alloy

Supercritical Co₂ Fluid Purification

A Greener Alternative to Liquid Chromatography

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Sustainable and High-Precision Chromatography with Supercritical CO₂

Supercritical Fluid Chromatography (SFC) is an eco-friendly and highly efficient purification process that offers a superior alternative to conventional liquid chromatography. By leveraging supercritical CO₂, SFC enables precise separation of high-value compounds while significantly reducing solvent consumption, waste, and energy use.

This scalable technology ensures high-purity results, making it ideal for pharmaceutical, nutraceutical, and natural product industries. The ability to remove unwanted contaminants, such as pesticides and heavy metals, further enhances its versatility.

Performance & Safety

01

Non-toxic, pure, and stable – CO₂-based purification with no solvent residues
 

02

Non-flammable – A safer alternative to organic solvents
 

03

Upcycled and recyclable CO₂ – Reduces environmental impact
 

04

Energy-efficient process – Lower operating costs compared to traditional methods
 

Precision Purification with Sustainable CO₂

At optimal temperature and pressure, CO₂ enters a supercritical phase, acting as an effective solvent with both gas-like diffusion and liquid-like solvation properties. This enables targeted extraction and purification of desired compounds, while efficiently removing impurities such as pesticides and residual solvents.

Unlike conventional liquid chromatography, SFC eliminates the need for toxic organic solvents, ensuring cleaner, purer final products and a significantly reduced ecological footprint.

Key Applications

01

Purification of omega-3 (EPA/DHA) and lipids
 

02

Separation of high-value natural extracts for fragrances and cosmetics
 

03

Selective removal of contaminants in plant-based extracts
 

04

Processing of vegetable oils and pharmaceutical ingredients
 

Flexible Purification for Every Scale

From small-batch R&D to full-scale industrial production, supercritical CO₂ purification can be customized and optimized to meet specific process requirements. Laboratory and pilot-scale testing ensure seamless scale-up, allowing manufacturers to maximize efficiency while minimizing costs and waste.

 

Need more info?

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Supercritical CO2 Solutions (EN)

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